I'm riding: Metric Century

Team: Team Leukemia

ID: 61800

Lifetime total: $9,855.00

Start time: 07:30 AM

I am riding In Memory of Ann Pearson.

I am riding In Honor of Rene Sutton.


I ride for my two aunts, one with CML and one with gastroesophageal cancer. The former is an example of how science changes cancer outcomes, the later remains a disease in need of better understanding and therapeutics. CML is associated with the BCR-ABL fusion protein, which causes constitutive ABL kinase activation and cell proliferation. Gleevec was develop to inhibit ABL kinase, and has transformed CML from an unrelenting progression to leukemic transformation and death into a chronic, manageable disease. In contrast, the molecular mechanism that drive gastroesophageal cancer remain poorly understood and we continue to rely on chemotherapy that targets rapidly growing cells rather than the molecular etiology of the disease. Understandably, the efficacy of this approach is modest and the toxicities can be significant.

I'm proud this year to ride with Team Leukemia. It is a group of physician-scientists at Washington University who work to understand how leukemia develops and how to apply modern sequencing into routine patient care.

I am proud to join Pedal the Cause in the fight against cancer. Pedal the Cause is more than the region's top cycling event. It's a way of life, a celebration, and a movement fueled by the courage to end cancer.

It takes world-class research to create a world without cancer. Please help me in this journey by donating to my ride, and give with confidence knowing that 100% of your donation will go directly to accelerating cancer research at Siteman Cancer Center and St. Louis Children's Hospital.

Through this effort, we hope to achieve better treatments for our patients here in St. Louis.